The paper presents the modeling of two-phase flow in turbulent flow. For this purpose, a two-fluid turbulence model is used. The work can be considered the development of a two-fluid approach to the problem of turbulence, which, unlike Reynolds' approach, leads to a closed system of equations. Therefore, the system of equations for a two-phase flow given in the work based on the two-fluid approach is also closed and no additional hypotheses are required. The resulting system of equations for a turbulent two-phase flow is implemented numerically for a two-phase flow in a cylindrical pipe and in a free jet. The obtained results are compared with known experimental data, as well as with the results of the Reynolds stress method (RSM). The results of the proposed model are in good agreement with experimental data. In addition, it is shown that the model adequately describes the phenomenon of “turbulent migration of particles, ” resulting in the accumulation of inertial particles on the axis and wall of the pipe.